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1540 CE
1550 CE
1560 CE
1570 CE
1580 CE
1590 CE
1600 CE
1610 CE
1620 CE
1630 CE
1640 CE
1543 CE: Three Portuguese mariners accidentally land in Japan, the first Europeans to do so.
1571 CE - 1639 CE: The Portuguese control the port of Nagasaki in Japan.
1571 CE: The Japanese daimyo Omura Sumitada grants the Portuguese control of Nagasaki.
1637 CE - 1638 CE: The Shimabara Rebellion in Japan, which the shogunate blames on Christians, leading to an expulsion of all Europeans.
1640 CE: A Portuguese embassy to negotiate a reopening of trade with Japan is unsuccessful and its members are executed.