The Pythia (or Oracle of Delphi) was the priestess who held court at Pytho, the sanctuary of the Delphinians, a sanctuary dedicated to the Greek god Apollo. Pythia were highly regarded, for it was believed that she channeled prophecies from Apollo himself, while steeped in a dreamlike trance. Originally the god was channeled only once a year, but at the height of its popularity up to three Pythiai were known to hold office. The sanctuary at Delphi was constructed in the 8th century BCE, and the final prophecy given around 393 CE, after the Roman emperor Theodosius ordered the closure of all pagan sanctuaries.
A Pythia was chosen among the priestesses of the temple upon the death of the previous Pythia. Moral character was of utmost importance, and even if the newly-chosen Pythia was married and had a family, she had to relinquish all familial duties in order to fill her role in the temple. Pythias were likely women from higher-class families, were educated, and well-read.
Definition
Timeline
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c. 800 BCEThe site of Delphi first acquires a religious significance.
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560 BCEThe oracles of Delphi and Thebes both tell King Croesus of Lydia that if he attacks the Medes, he will destroy a great empire. Seeing this as a good omen, he goes to war, loses, and the Lydian Empire is destroyed.
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393 CELast prophecy of the Oracle of Apollo at Delphi, after Roman Emperor Theodosius ordered the closure of all "pagan" sanctuaries.