Timeline
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1492 - 1493First Voyage of Christopher Columbus to the New World in three ships in an attempt to establish maritime trade routes to the East.
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1494A Spanish settlement is founded at La Isabela on the island of Hispaniola.
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7 Jun 1494Portugal and Spain sign the Treaty of Tordesillas which divides the world into two spheres of influence.
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1498The Spanish settlement of Santo Domingo on Hispaniola is founded.
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1502The encomienda system is first applied to the Americas on the island of Hispaniola.
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1503The use of the system of encomienda in the Spanish Empire receives approval from the Spanish monarchy.
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1508The Spanish first settle on Puerto Rico.
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1510The Spanish found Nombre de Dios in Panama.
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1511 - 1513Diego Velázquez de Cuéllar conducts the Spanish conquest of Cuba.
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1511The Spanish first settle on Cuba.
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1511The audiencia is formed in Santo Domingo, the first in the Spanish empire.
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1512The Laws of Burgos set out how indigenous peoples should be treated within the Spanish Empire.
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1513The jurist Juan López de Palacios Rubios is tasked with drafting the Spanish Requirement.
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Mar 1513 - Apr 1513Juan Ponce de León lands in Florida, the first documented European to do so.
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Jun 1513Juan Ponce de León discovers the Tortugas and the Gulf Stream.
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19 Jun 1513The notary Rodrigo de Colmemares reads out the Spanish Requirement for the first time to indigenous people in Colombia.
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Mar 1518Charles I of Spain formally accepts the proposal of Ferdinand Magellan to sail to Asia via the Americas.
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Apr 1518Juan de Grijalva leads an expedition to explore the eastern coast of Mexico.
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1519The Spanish found the city of Panama.
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1519Veracruz, Mexico is founded by Hernán Cortés.
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Nov 1519Motecuhzoma II receives Hernán Cortés at the Aztec capital Tenochtitlan.
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c. 1520 - 1789Spanish treasure fleets transport the riches of the Americas to Spain.
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30 Jun 1520The bloody retreat of Hernán Cortés from Tenochtitlan known as the Noche Triste ('Sad Night').
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1521Juan Ponce de León leads a second expedition to Florida to found a Spanish colony. His party is attacked and he dies of his wounds in Cuba.
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13 Aug 1521The Aztec capital of Tenochtitlan falls into the hands of Spanish forces led by Hernán Cortés.
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1522Jean de Fleury (aka Florin) captures three Spanish treasure ships off Cape Vincent.
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May 1523Hernán Cortés is appointed the first governor of the colony of New Spain (Mexico).
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1524 - 1834The Council of the Indies governs Spanish territories in the Americas.
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1524 - 1525Francisco Pizarro leads his first voyage of exploration to South America.
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Aug 1524The Council of the Indies is formed to govern Spanish colonies in the Americas.
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1526Francisco Pizarro leads his second voyage of exploration to South America.
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1527The audiencia is formed in Mexico City (formerly Tenochtitlan).
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Jul 1529Francisco Pizarro receives royal backing to explore South America.
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c. 1530The first Spanish galleons come into operation.
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Dec 1530Francisco Pizarro leaves Panama for his thrid voyage of exploration to South America.
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1532Francsico Pizarro and the Spanish conquistadors arrive in South America.
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15 Nov 1532Hernando de Soto reads out the Spanish Requirement to the Inca ruler Atahualpa.
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16 Nov 1532Battle of Cajamarca where the Inca leader Atahualpa is captured and held for ransom by Spanish forces led by Francisco Pizarro.
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15 Nov 1533Francisco Pizarro takes the Inca capital of Cuzco.
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1535Don Antonio de Mendoza is made the first viceroy of New Spain (Mexico and Central America).
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18 Jan 1535Francsico Pizarro founds Lima (Ciudad de Los Reyes) as the capital of Spanish Peru.
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Jul 1535Diego de Almagro leads a 20-month long expedition to explore Chile.
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6 May 1536An Inca army led by Manco Inca attackes the Spanish conquistadors in Cusco.
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1542The New Laws unsuccessfully attempt to reduce the application of the encomienda system in the Spanish Empire.
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1543The Spanish Viceroyalty of Peru (the former Inca territory) is established.
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Aug 1550The Valladolid debate between Juan Ginés de Sepúlveda and Bartolomé de Las Casas on how indigenous peoples in the Spanish Americas should be treated.
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1555Captain-General Pedro Menendez de Avilés begins a system of large and escorted convoys for the Spanish treasure fleets.
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Jul 1555The French privateer Jacques de Sores brutally attacks Havana.
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1565 - 1815The Manila galleons each year take eastern trade goods from Manila to Acapulco (and return with American silver).
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1572 - 1573Francis Drake explores Panama and seizes a Spanish silver mule train.
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1573Spanish royal regulations are issued on town planning in Spanish America.
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1573Philip II of Spain prohibits the application of the encomienda system in any new territories of the Spanish Empire.
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c. 1575 - 1820The repartimiento system of forced labour is practised in the Spanish Empire.
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Mar 1579Francis Drake captures the Spanish treasure ship Nuestra Señora de la Concepción (aka Cacafuego).
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1596Portobelo replaces Nombre de Dios as the chief Atlantic port in Panama.
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1599Dutch ships begin to take salt from Araya on the coast of Venezuela.
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1620 - 1697Buccaneers operate in the Caribbean and attack both ports and ships along the Spanish Main.
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1622The Nuestra Señora de Atocha Spanish treasure ship is wrecked in a storm off the Florida Keys.
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Sep 1628A Dutch force led by Admiral Hein captures the entire New Spain treasure fleet on its way to Havana.
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Apr 1669A buccaneer force led by Henry Morgan captures the port of Maracaibo. on the Spanish Main.
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1681The Nuestra Señora de Encarnación Spanish treasure ship is wrecked in a storm off the coast of Panama.
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1697The conquest of the Maya Civilization completed by the Spanish conquistador Martín de Ursúa.
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c. 1700The encomienda system goes into decline in most parts of the Spanish Empire.
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1714The military responsibilities of the Council of the Indies are transferred to the Spanish Ministry of the Navy and the Indies.
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1739The Spanish Viceroyalty of New Granada (Venezuela and Colombia) is established.
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1763The Treaty of Paris sees Spain cede Florida to Britain.
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1800Louisiana is ceded to France by the Spanish.